Description

2,5-Bis(Trifluoromethyl)Benzeneboronic Acid is a high-value organoboron building block characterized by its electron-deficient aromatic ring and boronic acid functional group. This compound is essential for modern synthetic chemistry, particularly in cross-coupling reactions like the Suzuki-Miyaura reaction, enabling the precise construction of complex molecules. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key synthon for constructing drug candidates, especially those requiring trifluoromethylated aromatic systems to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the CF3 groups enhance biological activity and environmental persistence.
• Materials Science: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers, liquid crystals, and organic electronic materials (OLEDs, OFETs).
• Chemical Research & Development: A versatile reagent for academic and industrial research in organometallic chemistry and catalysis.
• Ligand Synthesis: Used to prepare novel bidentate or polydentate ligands for transition metal catalysts.

Basic Information

Product Name	2,5-Bis(Trifluoromethyl)Benzeneboronic Acid
CAS No.	196083-18-8
Molecular Formula	C8H5BF6O2
Molecular Weight	257.93 g/mol
Synonyms	[2,5-Bis(trifluoromethyl)phenyl]boronic acid; 2,5-Bis(trifluoromethyl)phenylboronic acid; 2,5-Di(trifluoromethyl)benzeneboronic acid; (2,5-Bis(trifluoromethyl)phenyl)boronic acid; B-[2,5-Bis(trifluoromethyl)phenyl]boronic acid; 2,5-Bis(trifluoromethyl)benzeneboronic acid pinacol ester (protected form); 2,5-(CF3)2C6H3B(OH)2
EINECS	Contact for details

Quality Control

Our 2,5-Bis(Trifluoromethyl)Benzeneboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for sensitive coupling reactions. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive (store away from light). For long-term storage, consider storing under an inert atmosphere to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Standard Grade)
Assay (NMR)	≥95.0%
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.