Description

3-(1-Cbz-4-Piperidyl)-2-(Boc-Amino)Propanoic Acid is a sophisticated, dual-protected amino acid derivative designed for advanced organic synthesis. This compound is a critical building block for the controlled assembly of complex peptide and peptidomimetic structures, offering orthogonal deprotection strategies. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs) and bioactive molecules. Its high purity and defined stereochemistry are essential for ensuring the success of sensitive coupling reactions in drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic peptides and protease inhibitors.
• Peptide Synthesis: Serves as a protected amino acid residue in Solid-Phase Peptide Synthesis (SPPS) and solution-phase methodologies for constructing complex sequences.
• Chemical Biology Probes: Used to synthesize labeled or modified peptides for studying protein-protein interactions and enzyme mechanisms.
• Library Synthesis: Employed in combinatorial chemistry to generate diverse arrays of peptidomimetic compounds for high-throughput screening.
• API Development: Integral in the scalable synthesis of candidate drug molecules, particularly those targeting neurological and metabolic disorders.
• Academic Research: A valuable reagent in university and institutional labs for methodological development in organic and medicinal chemistry.

Basic Information

Product Name	3-(1-Cbz-4-Piperidyl)-2-(Boc-Amino)Propanoic Acid
CAS No.	195877-90-8
Molecular Formula	C21H30N2O6
Molecular Weight	406.48 g/mol
Synonyms	2-((tert-Butoxycarbonyl)amino)-3-(1-((benzyloxy)carbonyl)piperidin-4-yl)propanoic acid; Boc-NH-CH(CH2-1-Cbz-piperidin-4-yl)-COOH; N-Boc-3-(1-Cbz-4-piperidyl)alanine; (2R/S)-2-[(tert-Butoxycarbonyl)amino]-3-[1-(benzyloxycarbonyl)-4-piperidyl]propanoic acid; Fmoc/Boc Protected Amino Acid Derivative; CBZ-BOC Protected Piperidine Alanine; Peptide Building Block 195877-90-8
EINECS	Contact for details

Quality Control

Every batch of 3-(1-Cbz-4-Piperidyl)-2-(Boc-Amino)Propanoic Acid is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency meet the exacting standards required for pharmaceutical research. Certificates of Analysis (COA) detailing purity, chiral purity (where applicable), and impurity profiles are available upon request to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.