Description

2-Iodo-4-(Trifluoromethyl)Anisole, 97% is a high-purity, multi-functional halogenated aromatic building block essential for advanced organic synthesis. This compound is valued for its unique combination of iodine and trifluoromethyl substituents, which enable critical transformations in the development of complex molecules. It is primarily sought by researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries for applications in cross-coupling reactions and as a precursor for specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring trifluoromethyl and iodine functional groups for bioactivity or further derivatization.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and pesticides, where the trifluoromethyl group often enhances metabolic stability and lipophilicity.
• Material Science Precursor: Serves as a building block for advanced organic materials, including liquid crystals, organic semiconductors, and polymers with tailored electronic properties.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Sonogashira couplings, facilitating carbon-carbon bond formation.
• Ligand and Catalyst Development: Employed in the creation of specialized ligands and organocatalysts for asymmetric synthesis and other catalytic processes.
• Fluorine Chemistry Research: An important compound for studying the influence of fluorine atoms on molecular conformation, reactivity, and physical properties in medicinal and synthetic chemistry.

Basic Information

Item	Detail
Product Name	2-Iodo-4-(Trifluoromethyl)Anisole, 97%
CAS No.	195624-84-1
Molecular Formula	C8H6F3IO
Molecular Weight	302.04 g/mol
Synonyms	1-Iodo-2-methoxy-5-(trifluoromethyl)benzene; 2-Methoxy-α,α,α-trifluoro-5-iodotoluene; 5-Iodo-2-methoxybenzotrifluoride; 2-Iodo-α,α,α-trifluoro-p-anisole; 2-Iodo-4-(trifluoromethyl)methoxybenzene; 5-(Trifluoromethyl)-2-iodoanisole; 2-Methoxy-5-(trifluoromethyl)iodobenzene; 4-(Trifluoromethyl)-2-iodoanisole
EINECS	Contact for details

Quality Control

Our 2-Iodo-4-(Trifluoromethyl)Anisole, 97% is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, GC, and NMR to verify identity and assay. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This material is light-sensitive (store away from light). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residue on Ignition	< 0.1%
Solubility	Soluble in common organic solvents (e.g., DCM, THF, DMF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.