Description

tert-Butyl 5-Chloro-2-Hydroxybenzylcarbamate is a high-purity chemical intermediate of significant importance in modern synthetic chemistry. Its value lies in its role as a versatile building block for constructing more complex molecular architectures, particularly in pharmaceutical research and development. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of active ingredients and novel compounds.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging its halogenated phenolic structure.
• Peptidomimetics & PROTACs: Serves as a protected amine precursor in the design and synthesis of peptide mimics and Proteolysis Targeting Chimeras (PROTACs) for drug discovery.
• Material Science Research: Employed as a monomer or functionalization agent in the development of advanced polymers and specialty materials with specific properties.
• Chemical Biology Probes: Utilized to create molecular probes and tags for studying biological pathways and protein functions in academic and industrial research settings.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for clients.

Basic Information

Product Name	tert-Butyl 5-Chloro-2-Hydroxybenzylcarbamate
CAS No.	195517-88-5
Molecular Formula	C₁₂H₁₆ClNO₃
Molecular Weight	257.71 g/mol
Synonyms	5-Chloro-2-hydroxybenzylcarbamic acid tert-butyl ester; N-(tert-Butoxycarbonyl)-5-chloro-2-hydroxybenzylamine; tert-Butyl N-[(5-chloro-2-hydroxyphenyl)methyl]carbamate; Boc-5-chloro-2-hydroxybenzylamine; (5-Chloro-2-hydroxybenzyl)carbamic acid 1,1-dimethylethyl ester; 1,1-Dimethylethyl N-[(5-chloro-2-hydroxyphenyl)methyl]carbamate; BOC-5-Cl-2-OH-BnNH₂
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-Chloro-2-Hydroxybenzylcarbamate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment. We are committed to meeting the stringent requirements of cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Purity (HPLC, Area %)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.