Description

4-Fluoro-3-(Trifluoromethyl)Phenylacetic Acid is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring both fluorine and a trifluoromethyl group on the phenyl ring, makes it a critical intermediate for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries seeking to introduce these valuable fluorinated motifs into novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in developing kinase inhibitors, anti-inflammatory agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the fluorinated phenylacetic acid moiety enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals and organic light-emitting diode (OLED) materials, contributing to improved electronic properties and stability.
• Polymer & Resin Modifier: Incorporated as a monomer or additive to create specialty polymers with enhanced chemical resistance, thermal stability, and surface properties.
• Chemical Research & Development: A versatile reagent in medicinal chemistry and material science for structure-activity relationship (SAR) studies and the exploration of novel fluorinated compounds.

Basic Information

Product Name	4-Fluoro-3-(Trifluoromethyl)Phenylacetic Acid
CAS No.	195447-80-4
Molecular Formula	C9H6F4O2
Molecular Weight	222.14 g/mol
Synonyms	2-(4-Fluoro-3-(trifluoromethyl)phenyl)acetic Acid; 4-Fluoro-α-(trifluoromethyl)phenylacetic Acid; [4-Fluoro-3-(trifluoromethyl)phenyl]acetic Acid; 2-(4-Fluoro-3-trifluoromethylphenyl)acetic Acid; 195447-80-4; 4-Fluoro-3-trifluoromethylphenylacetic Acid; 4-Fluoro-3-trifluoromethylbenzeneacetic Acid
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-(Trifluoromethyl)Phenylacetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.