Description

2-Fluoro-3-(trifluoromethyl)phenylacetic acid is a high-value fluorinated aromatic building block essential for advanced organic synthesis. This compound matters for its unique trifluoromethyl and fluorine substituents, which are critical for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. It is primarily needed by researchers and manufacturers in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammatory diseases, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated compounds used in electronic displays and organic light-emitting diodes (OLEDs) due to its ability to improve charge transport and stability.
• Advanced Polymer Chemistry: Incorporated as a monomer or modifier to create specialty polymers with enhanced chemical resistance, thermal stability, and unique surface properties.
• Chemical Research & Development: A versatile reagent for Suzuki-Miyaura and other cross-coupling reactions to construct complex, multi-substituted biaryl systems in medicinal chemistry.
• Fluorine Chemistry Library Building: Employed in combinatorial chemistry and high-throughput screening to build diverse libraries of fluorinated compounds for drug discovery.

Basic Information

Product Name	2-Fluoro-3-(Trifluoromethyl)Phenylacetic Acid
CAS No.	194943-83-4
Molecular Formula	C9H6F4O2
Molecular Weight	222.14 g/mol
Synonyms	2-Fluoro-α-(trifluoromethyl)benzeneacetic acid; [2-Fluoro-3-(trifluoromethyl)phenyl]acetic acid; 3-(Trifluoromethyl)-2-fluorophenylacetic acid; 2-Fluoro-3-trifluoromethylphenylacetic acid; α-(2-Fluoro-3-(trifluoromethyl)phenyl)acetic acid; (2-Fluoro-3-(trifluoromethyl)phenyl)ethanoic acid; 2-Fluoro-3-(trifluoromethyl)benzeneacetic acid
EINECS	Contact for details

Quality Control

Our 2-Fluoro-3-(trifluoromethyl)phenylacetic acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support cGMP compliance for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases, oxidizing agents, and sources of ignition. For long-term storage under an inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.