Description

Rivastigmine D6 CAS NO 194930-00-2 is a deuterium-labeled analog of the acetylcholinesterase inhibitor Rivastigmine, serving as a critical internal standard for precise quantitative analysis. This stable isotope-labeled compound is essential for ensuring accuracy and reliability in bioanalytical methods, particularly in pharmacokinetic and metabolism studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in drug development and quality control.

Application

• Internal Standard for LC-MS/MS: Used as a quantitative reference standard in Liquid Chromatography-Tandem Mass Spectrometry for the accurate measurement of Rivastigmine in biological matrices like plasma and serum.
• Pharmacokinetic Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Metabolite Profiling: Aids in the identification and quantification of Rivastigmine metabolites during drug metabolism and pharmacodynamics (DMPK) studies.
• Bioanalytical Method Development & Validation: Critical for developing, optimizing, and validating robust analytical methods compliant with FDA, EMA, and ICH guidelines.
• Quality Control & Assurance: Supports in-house QC testing of active pharmaceutical ingredients (APIs) and finished drug products to ensure batch-to-batch consistency.
• Stability-Indicating Assays: Employed in studies to assess the stability of Rivastigmine under various storage and stress conditions.

Basic Information

Item	Detail
Product Name	Rivastigmine D6
CAS No.	194930-00-2
Molecular Formula	C14H16D6N2O2
Molecular Weight	254.35 g/mol
Synonyms	(S)-3-[1-(Dimethylamino)ethyl]phenyl D6-N-ethyl-N-methylcarbamate; Rivastigmine-d6; Rivastigmine (hexadeuterated); ENA 713-d6; SDZ ENA 713-d6; Exelon-d6; (S)-Rivastigmine D6; N-Ethyl-N-methylcarbamic acid 3-[(1S)-1-(dimethylamino)ethyl]phenyl ester-d6
EINECS	Contact for details

Quality Control

Our Rivastigmine D6 is manufactured under strict quality systems to ensure the high purity and isotopic enrichment required for analytical applications. Each batch undergoes comprehensive testing, including HPLC for chemical purity, NMR and MS for structural confirmation and isotopic enrichment, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (Deuterium Enrichment)	≥98.0 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.