Description

cis-Lurasidone HCl is a high-purity pharmaceutical intermediate and reference standard. This compound is critical for the research, development, and quality control of the atypical antipsychotic drug Lurasidone. It is primarily required by pharmaceutical manufacturers, analytical laboratories, and research institutions engaged in neuropharmacology and drug synthesis.

Application

• Primary reference standard for the analytical quantification of Lurasidone in Active Pharmaceutical Ingredients (APIs) and finished dosage forms.
• Key intermediate in the research-scale and process development synthesis of Lurasidone hydrochloride.
• Impurity standard for monitoring and controlling the isomeric purity of Lurasidone during manufacturing.
• Biochemical research tool for studying the pharmacological profile and receptor binding affinity of Lurasidone and its isomers.
• Calibration compound in High-Performance Liquid Chromatography (HPLC) and spectroscopic methods for method development and validation.
• Starting material for the synthesis of deuterated or other labeled analogs of Lurasidone for metabolic studies.

Basic Information

Product Name	cis-Lurasidone HCl
CAS No.	194861-82-0
Molecular Formula	C28H37ClN4O2S
Molecular Weight	529.13 g/mol
Synonyms	(3aR,4S,7R,7aS)-2-[(1R,2R)-2-[4-(1,2-Benzisothiazol-3-yl)piperazin-1-ylmethyl]cyclohexylmethyl]hexahydro-4,7-methano-2H-isoindole-1,3-dione hydrochloride; cis-Lurasidone Hydrochloride; Lurasidone cis-isomer HCl; SM-13496 (cis-isomer); UNII-8V7X8Y0Z8P (cis-isomer)
EINECS	Contact for details

Quality Control

Our cis-Lurasidone HCl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical research. A detailed Certificate of Analysis (COA) providing batch-specific results for identity, purity, and related substances is supplied with every order.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (cis-isomer)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.2%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.