Description

Acetylcholine Receptor Alpha1 (129-145) (Human, Bovine, Rat, Mouse) CAS NO 194737-11-6 is a synthetic peptide fragment corresponding to a specific extracellular region of the nicotinic acetylcholine receptor alpha1 subunit. This high-purity peptide is a critical research tool for studying receptor structure, function, and autoimmune disorders like myasthenia gravis. It is essential for neuroscientists, immunologists, and pharmaceutical researchers engaged in neurobiology, antibody screening, and therapeutic development.

Application

• Antigen for Antibody Production: Used to generate and screen polyclonal or monoclonal antibodies specific to the acetylcholine receptor.
• Immunoassay Development: Serves as a coating or competing antigen in ELISA, RIA, and other immunoassays to detect autoantibodies in patient sera.
• Biochemical Research: Employed in competitive binding studies, epitope mapping, and investigations into receptor-ligand interactions.
• Diagnostic Reagent Component: A key component in in-vitro diagnostic kits for the detection of myasthenia gravis and related autoimmune conditions.
• Neuroscience Studies: Utilized to probe the role of specific receptor domains in synaptic function and signal transduction.
• Vaccine Research: Investigated as a potential immunogen in experimental models of autoimmune disease.

Basic Information

Product Name	Acetylcholine Receptor Alpha1 (129-145) (Human, Bovine, Rat, Mouse)
CAS No.	194737-11-6
Molecular Formula	C78H124N22O23S
Molecular Weight	1786.0 g/mol
Synonyms	Acetylcholine Receptor Subunit Alpha Peptide (129-145); nAChR α1 (129-145); AChR-alpha (129-145); Nicotinic Acetylcholine Receptor Alpha 1 Subunit Fragment; Torpedo Californica Acetylcholine Receptor α-Subunit (129-145); Autoantigen Peptide for Myasthenia Gravis; H-Trp-Thr-Asp-Tyr-Gly-Thr-Lys-Ile-Val-Trp-Tyr-Pro-Asp-His-Phe-Gln-Lys-OH
EINECS	Contact for details

Quality Control

Every batch of our Acetylcholine Receptor Alpha1 (129-145) peptide is manufactured and tested under stringent conditions to ensure the highest standards of identity, purity, and biological suitability. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing results from multiple orthogonal analytical methods including HPLC, MS, and AAA. Our quality system supports research requiring reproducible and reliable biochemical reagents.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep the lyophilized powder at -20°C or below in a dry environment. Once reconstituted, aliquot and store frozen at -80°C to avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass confirmed
Purity (HPLC)	≥ 95%
Amino Acid Composition	Conforms to theoretical values (±10%)
Peptide Content	≥ 70% (by weight)
Solubility	Soluble in water or dilute aqueous acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.