Description

Hs-Peg6-Oh CAS NO 194425-46-2 is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a hexaethylene glycol spacer terminated with a hydroxyl group. This compound is a critical building block in bioconjugation and pharmaceutical development, enabling the precise modification of biomolecules to enhance their solubility, stability, and pharmacokinetic properties. It is essential for researchers and manufacturers in the fields of biopharmaceuticals, advanced drug delivery systems, and diagnostic reagent development.

Application

• Bioconjugation Linker: Used for coupling drugs, proteins, or peptides to carriers like antibodies or nanoparticles.
• PEGylation Reagent: Serves as a key intermediate in the synthesis of PEGylated therapeutics to reduce immunogenicity and prolong circulation half-life.
• Crosslinking Agent: Facilitates the formation of hydrogels and polymer networks for controlled release applications.
• Surface Modification: Imparts hydrophilicity and anti-fouling properties to biomaterial surfaces and medical devices.
• Diagnostic Probes: Utilized in the development of fluorescent or radioactive probes for imaging and detection.
• Solubility Enhancer: Improves the aqueous solubility of poorly soluble active pharmaceutical ingredients (APIs).
• Organic Synthesis Intermediate: Acts as a versatile spacer or protecting group in complex synthetic pathways.

Basic Information

Item	Details
Product Name	Hs-Peg6-Oh
CAS No.	194425-46-2
Molecular Formula	C14H30O8
Molecular Weight	326.39 g/mol
Synonyms	1-Amino-3,6,9,12,15,18-hexaoxahenicosan-21-ol; 21-Hydroxy-3,6,9,12,15,18-hexaoxahenicosan-1-amine; Heterobifunctional PEG6 alcohol; Amino-PEG6-OH; NH2-PEG6-OH; HS-PEG6-OH; 6-Amino-3,6,9,12,15,18-hexaoxahexacosan-1-ol; PEG Spacer 6 with terminal amine and hydroxyl groups
EINECS	Contact for details

Quality Control

Our Hs-Peg6-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry to ensure identity and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your regulatory and R&D needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and easily oxidized nature. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Molecular Weight (MS)	326.39 ± 2

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.