Description

2',6'-Dimethylcarbonylphenyl-10-Sulfopropylacridinium-9-Carboxylate 4'-NHS Ester is a highly reactive, activated ester derivative of an acridinium compound, designed for efficient covalent conjugation. This specialized reagent is critical for creating stable, chemiluminescent labels for biomolecules, offering superior signal-to-noise ratios in sensitive detection assays. It is primarily utilized by researchers and manufacturers in the in-vitro diagnostics (IVD), life sciences, and pharmaceutical development sectors for developing advanced immunoassays and nucleic acid probes.

Application

• Chemiluminescent Immunoassay (CLIA) Development: As a key labeling reagent for antibodies and antigens in automated clinical diagnostic systems.
• Nucleic Acid Probe Labeling: For the synthesis of chemiluminescent probes used in hybridization assays and molecular diagnostics.
• Protein and Peptide Conjugation: Enabling the site-specific labeling of proteins for research and diagnostic applications.
• Biosensor Fabrication: Immobilization of biomolecules on sensor surfaces to create sensitive detection platforms.
• High-Throughput Screening (HTS) Reagents: Production of labeled ligands and substrates for drug discovery assays.
• Lateral Flow Assay (LFA) Enhancement: Development of highly sensitive, quantitative lateral flow tests.

Basic Information

Product Name	2',6'-Dimethylcarbonylphenyl-10-Sulfopropylacridinium-9-Carboxylate 4'-NHS Ester
CAS No.	194357-64-7
Molecular Formula	C31H28N2O8S
Molecular Weight	588.63 g/mol
Synonyms	NHS-Activated Acridinium Ester; 10-(3-Sulfopropyl)acridinium-9-carboxylate 2',6'-dimethyl-4'-(N-succinimidyloxycarbonyl)phenyl ester; Acridinium NHS Ester; Sulfopropylacridinium NHS Ester; Chemiluminescent Labeling Reagent; CLIA Labeling Agent; Lumigen APS-5 derivative; N-Hydroxysuccinimide ester of acridinium carboxylic acid
EINECS	Contact for details

Quality Control

Every batch of our 2',6'-Dimethylcarbonylphenyl-10-Sulfopropylacridinium-9-Carboxylate 4'-NHS Ester is manufactured and tested under strict quality management systems to ensure high purity, consistent reactivity, and batch-to-batch reproducibility, which are critical for diagnostic assay performance. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed HPLC purity, identity confirmation (NMR/IR), and functional performance data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term stability, store under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Functional Activity (Labeling Efficiency)	Conforms to reference standard
Single Spot (TLC)	One major spot

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.