Description

4-Chloro-2-Fluorophenylacetic Acid is a versatile fluorinated aromatic building block of significant importance in advanced organic synthesis. Its core value lies in its bifunctional structure, featuring both a reactive carboxylic acid group and a halogenated aromatic ring, making it a critical intermediate for constructing complex molecules. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for anti-inflammatory and central nervous system (CNS) targeted drugs.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where the fluorine and chlorine substituents enhance biological activity and environmental stability.
• Liquid Crystal Material Precursor: Serves as a starting material for the synthesis of fluorinated liquid crystal compounds used in display technologies.
• Organic Ligand Synthesis: Utilized to prepare specialized ligands for catalysis and material science applications.
• Custom Chemical Synthesis: Employed in contract research and manufacturing (CRAM) for bespoke molecule construction and process development.

Basic Information

Product Name	4-Chloro-2-Fluorophenylacetic Acid
CAS No.	194240-75-0
Molecular Formula	C8H6ClFO2
Molecular Weight	188.58 g/mol
Synonyms	2-(4-Chloro-2-fluorophenyl)acetic Acid; (4-Chloro-2-fluorophenyl)acetic Acid; 4-Chloro-2-fluorobenzeneacetic Acid; 2-Fluoro-4-chlorophenylacetic Acid; NSC 405124; 4-Chloro-2-fluoro-α-toluic Acid
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Fluorophenylacetic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical and agrochemical applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	95 - 100 °C
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Any individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.