Description

n-Boc-n-(2-Methylpropyl)-Glycine is a protected amino acid derivative, specifically a glycine analog bearing a tert-butoxycarbonyl (Boc) protecting group on the nitrogen and an isobutyl side chain. This compound is a crucial high-purity building block in the synthesis of complex peptides and peptidomimetics, offering precise control over molecular architecture. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery and the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs) and investigational new drugs.
• Peptide Synthesis: Serves as a protected amino acid residue in solid-phase and solution-phase peptide synthesis (SPPS) for creating custom peptide sequences.
• Proteomics Research: Used in the design and construction of peptide probes, substrates, and inhibitors for enzyme studies and biochemical assays.
• Chemical Biology: Incorporation into peptidomimetics and macrocyclic compounds to modulate biological activity and improve metabolic stability.
• Agrochemical Development: Potential intermediate in the research and synthesis of novel peptide-based agrochemicals.

Basic Information

Product Name	n-Boc-n-(2-Methylpropyl)-Glycine
CAS No.	194206-80-9
Molecular Formula	C₁₁H₂₁NO₄
Molecular Weight	231.29 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-N-(2-methylpropyl)glycine; Boc-Nle-Gly-OH; N-Boc-N-isobutylglycine; 2-[[(2-Methylpropyl)(tert-butoxycarbonyl)amino]acetic acid; (2-((tert-Butoxycarbonyl)(isobutyl)amino)acetic acid); N-α-Boc-N-δ-isobutylglycine; Boc-N(isobutyl)-Gly-OH
EINECS	Contact for details

Quality Control

Our n-Boc-n-(2-Methylpropyl)-Glycine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via NMR and IR spectroscopy. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.