Description

(S)-1-[(R)-2-(Dicyclohexylphosphino)Ferrocenyl]Ethyldi-tert-Butylphosphine is a highly specialized chiral ferrocenyl phosphine ligand, a cornerstone in modern asymmetric catalysis. Its value lies in its ability to induce exceptional enantioselectivity and high catalytic activity in transition metal-catalyzed reactions, enabling the efficient synthesis of single-enantiomer compounds. This ligand is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control for developing advanced intermediates and active ingredients.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, ketones, and imines, critical for producing chiral alcohols and amines in pharmaceutical synthesis.
• Cross-Coupling Reactions: Employed in asymmetric versions of Suzuki-Miyaura, Buchwald-Hartwig, and other C-C/C-N bond-forming reactions to create stereogenic centers.
• Pharmaceutical Intermediate Synthesis: Key for constructing complex, chiral molecular scaffolds found in active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Manufacturing: Used in the production of enantiomerically pure herbicides, fungicides, and plant growth regulators for enhanced efficacy and environmental safety.
• Fine Chemical and Fragrance Production: Facilitates the synthesis of high-value chiral flavor and fragrance compounds.
• Academic and Industrial R&D: A vital tool for methodology development and exploring new catalytic transformations in both academic and industrial research laboratories.

Basic Information

Product Name	(S)-1-[(R)-2-(Dicyclohexylphosphino)Ferrocenyl]Ethyldi-tert-Butylphosphine
CAS No.	194020-16-1
Molecular Formula	C34H52FeP2
Molecular Weight	578.56 g/mol
Synonyms	(S,R)-Josiphos; (S)-1-[(R)-2-(Dicyclohexylphosphino)ferrocenyl]ethyldi(tert-butyl)phosphine; Josiphos SL-J009-1; (S)-1-((R)-2-(Dicyclohexylphosphino)ferrocenyl)ethyldi-tert-butylphosphine; (S)-1-[(R)-2-(Dicyclohexylphosphino)ferrocenyl]ethyl-di-tert-butylphosphine; (S)-1-[(R)-2-(Dicyclohexylphosphino)ferrocenyl]ethylbis(1,1-dimethylethyl)phosphine; SL-J009-1; Josiphos Ligand
EINECS	Contact for details

Quality Control

Our (S)-1-[(R)-2-(Dicyclohexylphosphino)Ferrocenyl]Ethyldi-tert-Butylphosphine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high chemical purity and chiral integrity. Certificates of Analysis (COA) with detailed specifications are provided to guarantee consistency and traceability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C or as specified on the label or COA. This compound is easily oxidized and moisture-sensitive; prolonged exposure to air or ambient conditions should be avoided to maintain stability and performance.

Specification

Item	Specification
Appearance	Orange to red-brown powder or crystals
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.