Description

Fmoc-L-β-Homoleucine CAS NO 193887-44-4 is a high-purity, non-proteinogenic amino acid derivative specifically engineered for advanced peptide synthesis. This compound is critical for researchers and manufacturers who require precise control over peptide chain length and side-chain functionality to develop novel bioactive molecules. It is an essential building block for pharmaceutical R&D, particularly in the development of peptide-based therapeutics, diagnostic agents, and complex chemical libraries.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, enabling the controlled assembly of complex peptide sequences.
• Pharmaceutical Intermediates: Serves as a crucial intermediate in the synthesis of peptide drugs targeting metabolic disorders, oncology, and infectious diseases.
• Combinatorial Chemistry: Used to create diverse peptide libraries for high-throughput screening in drug discovery programs.
• Bioconjugation: Facilitates the site-specific modification of peptides and proteins for creating antibody-drug conjugates (ADCs) or diagnostic probes.
• Academic & Industrial Research: Employed in studying protein folding, structure-activity relationships (SAR), and enzyme-substrate interactions.
• Production of Custom Peptides: Used by CROs and CDMOs for the contract manufacturing of non-standard peptides for clinical and research applications.

Basic Information

Product Name	Fmoc-L-β-Homoleucine
CAS No.	193887-44-4
Molecular Formula	C22H25NO4
Molecular Weight	367.44 g/mol
Synonyms	Fmoc-β-hLeu-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-β-homoleucine; Fmoc-L-β-Hle-OH; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-4-methylpentanoic acid; Fmoc-β-Homo-L-leucine; N-Fmoc-L-β-homoleucine; Fmoc-(β-Homo)Leu-OH; Fmoc-L-β-Homoleucine
EINECS	Contact for details

Quality Control

Our Fmoc-L-β-Homoleucine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to cGMP guidelines where applicable, and our quality systems support development from research to commercial scale, ensuring compliance with global regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Specific Rotation	-20.0° to -24.0° (c=1, DMF)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.