Description

(S)-n-Fmoc-Octylglycine is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis. This compound is critical for introducing hydrophobic, long-chain alkyl modifications into peptide sequences, enabling the fine-tuning of biological activity and physicochemical properties. It is an essential building block for researchers and manufacturers in pharmaceutical development, particularly for creating novel peptide therapeutics, diagnostic agents, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc-strategy, used to incorporate an octylglycine side chain into peptide backbones.
• Pharmaceutical R&D: Synthesis of peptide drug candidates targeting GPCRs, antimicrobial peptides (AMPs), and lipopeptide vaccines where enhanced lipophilicity and membrane interaction are desired.
• Structure-Activity Relationship (SAR) Studies: Used to systematically modify peptide structures to investigate the effect of hydrophobic side chain length on potency, selectivity, and metabolic stability.
• Bioconjugation and Probe Development: Serves as a precursor for creating fluorescently labeled or affinity-tagged peptides for imaging and biochemical assays.
• Material Science: Incorporation into peptide-based polymers and surfactants to control self-assembly and surface properties.

Basic Information

Product Name	(S)-n-Fmoc-Octylglycine
CAS No.	193885-59-5
Molecular Formula	C25H31NO4
Molecular Weight	409.52 g/mol
Synonyms	Fmoc-Octyl-Gly-OH; Fmoc-N-octylglycine; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)decanoic acid; N-α-Fmoc-N-octylglycine; N-Fmoc-N-octylglycine; N-(9-Fluorenylmethoxycarbonyl)-N-octylglycine; Fmoc-N-C8-Gly-OH; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(octyl)amino)acetic acid
EINECS	Contact for details

Quality Control

Our (S)-n-Fmoc-Octylglycine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and NMR for structural confirmation. Certificates of Analysis (COA) with detailed chromatographic data are provided to ensure traceability and batch-to-batch consistency, meeting the stringent requirements of research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.