Description

Fmoc-Nip-Oh CAS NO 193693-68-4 is a high-purity, protected amino acid derivative essential for modern solid-phase peptide synthesis (SPPS). This compound serves as a critical building block, enabling the controlled and efficient assembly of complex peptide sequences. It is primarily utilized by research institutions, pharmaceutical developers, and fine chemical manufacturers engaged in the production of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the sequential construction of custom peptides.
• Pharmaceutical Research: Intermediate in the development and scale-up of novel peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Bioconjugation: Used to introduce specific functional groups or linkers into peptides for labeling or conjugation with other biomolecules.
• Combinatorial Chemistry: A valuable reagent in libraries for high-throughput screening to discover new bioactive compounds.
• Academic & Institutional Research: Fundamental building block for studying peptide structure, function, and interactions in biochemistry and molecular biology labs.
• Production of Specialty Peptides: Manufacture of peptides for cosmetic applications, nutritional supplements, and agrochemical research.

Basic Information

Product Name	Fmoc-Nip-Oh
CAS No.	193693-68-4
Molecular Formula	C₂₀H₂₁NO₅
Molecular Weight	355.39 g/mol
Synonyms	Fmoc-Nip-OH; (9H-Fluoren-9-yl)methyl (2S)-2-[[(2S)-2-(4-hydroxyphenyl)-2-(methoxycarbonyl)amino]acetyl]amino]-3-phenylpropanoate; Fmoc-N-methylated phenylalanine derivative; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-iodo-L-phenylalanine; Fmoc-N-iodo-L-Phe-OH (related protected form); N-Fmoc-3-(4-hydroxyphenyl)-N-methyl-L-alanine; Peptide synthesis building block 193693-68-4
EINECS	Contact for details

Quality Control

Our Fmoc-Nip-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive peptide synthesis applications. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep the container tightly sealed in a desiccated environment after opening.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.