Description

(R)-1-Fmoc-Piperidine-3-Carboxylic Acid is a high-purity, enantiomerically pure chiral building block used in advanced organic synthesis. This compound is critical for the development of novel pharmaceuticals and bioactive molecules, particularly in the field of peptide and peptidomimetic chemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, process development, and the synthesis of complex active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, especially those targeting neurological and metabolic disorders.
• Peptidomimetic Synthesis: Used to incorporate constrained, non-natural amino acid motifs into peptide backbones to enhance stability and bioavailability.
• Solid-Phase Peptide Synthesis (SPPS): Serves as a protected amino acid derivative for the Fmoc-strategy, enabling the sequential assembly of peptides.
• Chemical Biology & Proteomics: Employed in the design and synthesis of enzyme inhibitors, receptor ligands, and molecular probes for biological studies.
• Asymmetric Catalysis Research: Acts as a precursor for chiral ligands or catalysts used in enantioselective transformations.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects requiring high stereochemical purity.

Basic Information

Product Name	(R)-1-Fmoc-Piperidine-3-Carboxylic Acid
CAS No.	193693-67-3
Molecular Formula	C22H23NO4
Molecular Weight	365.42 g/mol
Synonyms	(R)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]piperidine-3-carboxylic Acid; (R)-N-Fmoc-piperidine-3-carboxylic Acid; (R)-1-Fmoc-3-piperidinecarboxylic Acid; (3R)-1-(9H-Fluoren-9-ylmethoxycarbonyl)piperidine-3-carboxylic Acid; Fmoc-(R)-3-piperidinecarboxylic Acid; (R)-1-[(9-Fluorenylmethoxy)carbonyl]piperidine-3-carboxylic Acid; (R)-Fmoc-Pip(3)-OH
EINECS	Contact for details

Quality Control

Our (R)-1-Fmoc-Piperidine-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.