Description

4A(2H)-Naphthalenecarbonitrile,1,3,4,5,6,7-Hexahydro-7-Oxo-,(S)-(9Ci) is a high-purity, chiral synthetic intermediate of significant importance in advanced organic synthesis. Its defined stereochemistry and functionalized naphthalene core make it a valuable building block for constructing complex molecular architectures. This compound is primarily sought by research and development teams in the pharmaceutical and fine chemical industries for applications in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and anti-inflammatory targets.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in catalytic asymmetric reactions to introduce stereochemical complexity.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Fine Chemical Production: Used in the manufacture of specialty chemicals, agrochemicals, and advanced materials requiring specific chiral motifs.
• Academic & Contract Research: Supports chemical research in academic institutions and contract research organizations (CROs) for method development and novel compound libraries.

Basic Information

Product Name	4A(2H)-Naphthalenecarbonitrile,1,3,4,5,6,7-Hexahydro-7-Oxo-,(S)-(9Ci)
CAS No.	193222-44-5
Molecular Formula	C₁₁H₁₁NO
Molecular Weight	173.21 g/mol
Synonyms	(S)-1,3,4,5,6,7-Hexahydro-7-oxo-4a(2H)-naphthalenecarbonitrile; (S)-4a,5,6,7,8,8a-Hexahydro-4a-cyano-1(2H)-naphthalenone; (S)-7-Oxo-1,2,3,4,5,6,7,8-octahydro-4a-cyano-naphthalene; (S)-Octahydro-7-oxo-4a-cyano-naphthalene; (S)-4a-Cyano-5,6,7,8-tetrahydro-1(2H)-naphthalenone; 4a(2H)-Naphthalenecarbonitrile, 1,3,4,5,6,7-hexahydro-7-oxo-, (S)-; (S)-enantiomer of 193222-44-5
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide material with a typical purity of ≥97% (by HPLC), with enantiomeric excess (ee) specifications available. Certificates of Analysis (COA) detailing identity, purity, and chiral purity are available upon request. Our quality system supports development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is moisture-sensitive; ensure the container is kept sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.