Description

n-(3-Methoxy-3-Oxopropyl)-L-Valine tert-Butyl Ester is a protected amino acid derivative of significant value in advanced organic synthesis. This compound serves as a crucial chiral building block for the construction of complex peptide and peptidomimetic structures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of peptide-based drugs and protease inhibitors.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to introduce the L-valine moiety with orthogonal protecting groups.
• Bioconjugation: Serves as a linker or spacer molecule in the design of antibody-drug conjugates (ADCs) and other bioconjugates.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and the exploration of new pharmacophores.
• Fine Chemical Synthesis: A building block for creating specialized non-peptide molecules requiring a protected amino acid functionality.

Basic Information

Product Name	n-(3-Methoxy-3-Oxopropyl)-L-Valine tert-Butyl Ester
CAS No.	192725-86-3
Molecular Formula	C14H25NO5
Molecular Weight	287.35 g/mol
Synonyms	L-Valine, N-(3-methoxy-3-oxopropyl)-, 1,1-dimethylethyl ester; tert-Butyl N-[3-(methoxycarbonyl)propyl]-L-valinate; (S)-tert-Butyl 2-((3-methoxy-3-oxopropyl)amino)-3-methylbutanoate; Boc-L-Valine(OMe)-OtBu derivative; Protected L-Valine ester
EINECS	Contact for details

Quality Control

Our n-(3-Methoxy-3-Oxopropyl)-L-Valine tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.