Description

Mca-Pro-Leu-Ala-Gln-Ala-Val-Dap(Dnp)-Arg-Ser-Ser-Ser-Arg-Nh2 is a synthetic, fluorogenic peptide substrate designed for high-sensitivity enzymatic assays. This compound is critically important for biochemical research and pharmaceutical development, specifically for the study and quantification of protease activity. It is primarily needed by biotechnology companies, academic research institutions, and pharmaceutical R&D laboratories focused on enzymology, drug discovery, and diagnostic assay development.

Application

• Protease Activity Assays: As a specialized fluorogenic substrate for measuring the kinetic activity of specific proteolytic enzymes.
• Drug Discovery Screening: Used in high-throughput screening (HTS) platforms to identify and characterize potential protease inhibitors as therapeutic candidates.
• Biochemical Research: A key tool for studying enzyme kinetics, substrate specificity, and catalytic mechanisms in purified enzyme systems.
• Diagnostic Development: Serves as a core component in the development of sensitive in-vitro diagnostic tests for diseases linked to abnormal protease levels.
• Quality Control in Biologics: Employed to monitor and validate the activity and consistency of enzyme-based biopharmaceutical products during manufacturing.

Basic Information

Product Name	Mca-Pro-Leu-Ala-Gln-Ala-Val-Dap(Dnp)-Arg-Ser-Ser-Ser-Arg-Nh2
CAS No.	192723-42-5
Molecular Formula	C68H106N24O22
Molecular Weight	1563.7 g/mol
Synonyms	Mca-PL-A-Q-A-V-K(Dnp)-R-S-S-S-R-NH2; (7-Methoxycoumarin-4-yl)acetyl-Pro-Leu-Ala-Gln-Ala-Val-Lys(Dnp)-Arg-Ser-Ser-Ser-Arg-amide; Fluorogenic Protease Substrate IV; Mca-PLAQAVK(Dnp)RSSSR-NH2; Calpain Substrate II; CAS 192723-42-5
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing key parameters such as purity (by HPLC), peptide content, and water content. Production follows strict quality management protocols suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 70.0%
Water Content (KF)	≤ 8.0%
Solubility	Soluble in DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.