Description

(R)-(-)-4,12-Bis(Diphenylphosphino)-[2.2]-Paracyclophane is a highly specialized chiral diphosphine ligand with the CAS number 192463-40-4. This compound is critically important for enabling highly enantioselective transformations in asymmetric catalysis, a cornerstone of modern pharmaceutical and fine chemical synthesis. It is an essential tool for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries who require precise stereochemical control.

Application

• As a chiral ligand for asymmetric hydrogenation reactions, crucial for producing single-enantiomer pharmaceutical intermediates.
• In asymmetric C-C bond-forming reactions, such as cross-coupling and allylic alkylation, for constructing complex chiral molecules.
• For the development of novel catalytic systems in academic and industrial research focused on green chemistry and atom economy.
• As a key component in the synthesis of enantiomerically pure agrochemicals and flavors & fragrances.
• In the preparation of chiral metal complexes used as catalysts or materials with specific optical properties.
• For process optimization and scale-up in the production of chiral active pharmaceutical ingredients (APIs).

Basic Information

Item	Details
Product Name	(R)-(-)-4,12-Bis(Diphenylphosphino)-[2.2]-Paracyclophane
CAS No.	192463-40-4
Molecular Formula	C40H32P2
Molecular Weight	574.63 g/mol
Synonyms	(R)-(-)-4,12-Bis(diphenylphosphino)[2.2]paracyclophane; (R)-PhanePHOS; (R)-4,12-Bis(diphenylphosphino)-[2.2]-paracyclophane; (R)-Bis(diphenylphosphino)[2.2]paracyclophane; (R)-(-)-PhanePHOS; (R)-DPP-PCP; (R)-[2.2]Paracyclophane-4,12-diylbis(diphenylphosphine); (R)-1,1'-[1,2-Phenylenebis(methylene)]bis[1,1-diphenylphosphine]
EINECS	Contact for details

Quality Control

Our (R)-(-)-4,12-Bis(Diphenylphosphino)-[2.2]-Paracyclophane is produced and handled under strict quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chiral purity (enantiomeric excess), chemical purity, and identity confirmation. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Due to its sensitivity to oxidation, this material should be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended long-term storage temperature is 2-8°C. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.