Description

(R,R)-Hydroxy Bupropion is a key chiral metabolite and synthetic intermediate of the widely used antidepressant and smoking cessation aid, bupropion. This high-purity enantiomer is critical for advanced pharmaceutical research and development, particularly in the study of metabolic pathways, receptor selectivity, and enantiomer-specific pharmacological activity. It serves as an essential building block for medicinal chemists and analytical scientists in the pharmaceutical and biotechnology sectors, enabling the development of more targeted and efficacious therapeutic agents.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantitative and qualitative analysis of bupropion and its metabolites in bioanalytical studies, clinical trials, and pharmacokinetic research.
• Metabolite Research: Essential for investigating the metabolic fate, activity, and potential toxicity of the (R,R)-enantiomer of hydroxybupropion in preclinical and clinical settings.
• Chiral Synthesis Intermediate: Serves as a high-value precursor in the asymmetric synthesis of novel bupropion analogs or other complex molecules requiring this specific chiral scaffold.
• Pharmacology & DMPK Studies: Employed in drug metabolism and pharmacokinetics (DMPK) studies to understand enantioselective absorption, distribution, metabolism, and excretion (ADME).
• Analytical Method Development: Crucial for developing and validating sensitive chromatographic methods (e.g., Chiral HPLC) to separate and quantify bupropion enantiomers and their metabolites.
• Impurity Profiling: Used to identify, characterize, and control specified and unspecified impurities in bupropion drug substance and finished product manufacturing, supporting regulatory filings.

Basic Information

Product Name	(R,R)-Hydroxy Bupropion
CAS No.	192374-15-5
Molecular Formula	C13H18ClNO2
Molecular Weight	255.74 g/mol
Synonyms	(2R,3R)-Hydroxybupropion; (R,R)-Hydroxybupropion; (2R,3R)-2-(tert-Butylamino)-1-(3-chlorophenyl)propan-1-ol; (1R,2R)-2-(tert-Butylamino)-1-(3-chlorophenyl)propan-1-ol; BW 306U; Metabolite Hydroxy Bupropion (R,R)-form; (R,R)-2-(tert-Butylamino)-3'-chloropropiophenone alcohol
EINECS	Contact for details

Quality Control

Every batch of (R,R)-Hydroxy Bupropion is manufactured and analyzed under strict quality management systems. Our products undergo rigorous identity, purity, and chiral purity testing using advanced analytical techniques such as HPLC, Chiral HPLC, and NMR to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment to guarantee traceability and support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.