Description

(S,S)-Hydroxy Bupropion is a key chiral metabolite and active pharmaceutical ingredient (API) intermediate of the antidepressant and smoking cessation drug bupropion. This high-purity enantiomer is critical for pharmaceutical research and development, enabling precise studies into metabolic pathways, pharmacological activity, and the development of enantiomerically pure therapeutics. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in advanced drug metabolism and pharmacokinetics (DMPK) studies, neuropharmacology research, and the synthesis of novel chiral compounds.

Application

• Pharmaceutical Intermediate: A crucial chiral building block for the synthesis of bupropion and its related analogs.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical methods (LC-MS/MS) for quantifying bupropion metabolites in pharmacokinetic and clinical studies.
• Drug Metabolism Research: Essential for in vitro and in vivo studies investigating the stereoselective metabolism, efficacy, and toxicity profile of bupropion.
• Chiral Pharmacology Studies: Enables research into the distinct biological activity and receptor binding affinity of individual bupropion enantiomers and metabolites.
• Impurity Standard: Serves as a certified reference material for identifying and controlling chiral impurities in bupropion API manufacturing.
• Neurological Research: Applied in preclinical research to study mechanisms related to dopamine and norepinephrine reuptake inhibition.

Basic Information

Product Name	(S,S)-Hydroxy Bupropion
CAS No.	192374-14-4
Molecular Formula	C13H18ClNO2
Molecular Weight	255.74 g/mol
Synonyms	(2S,3S)-Hydroxybupropion; (S,S)-2-(tert-Butylamino)-1-(3-chlorophenyl)propan-1-ol; (S,S)-Hydroxybupropion HCl (if applicable); BW 306U; Major chiral metabolite of Bupropion; (1S,2S)-2-(tert-Butylamino)-1-(3-chlorophenyl)propan-1-ol; Threo-Hydroxybupropion (S,S-isomer)
EINECS	Contact for details

Quality Control

Our (S,S)-Hydroxy Bupropion is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral HPLC for enantiomeric purity, NMR and MS for structural confirmation, and stringent control of residual solvents and related substances. We provide full traceability and Certificates of Analysis (COA) detailing purity, identity, and assay results to support regulatory filings and GLP/GMP research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound may be hygroscopic; therefore, containers should be kept tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.