Description

(R)-(+)-2,2'-Bis[Di(3,5-Di-T-Butylphenyl)Phosphino]-6,6'-Dimethoxy-1,1'-Biphenyl,Min.97% is a high-purity, chiral bisphosphine ligand essential for asymmetric catalysis. This compound matters because it enables highly selective and efficient synthesis of complex chiral molecules, which are critical for producing advanced pharmaceuticals and fine chemicals. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require precise stereochemical control in their catalytic reactions.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in pharmaceutical intermediate synthesis.
• Asymmetric C-C Bond Formation: Used in cross-coupling and addition reactions to construct chiral centers with high enantiomeric excess.
• Catalyst Development: Serves as a critical component in the design and screening of novel transition metal catalysts for academic and industrial research.
• Process Chemistry: Employed in the scale-up and optimization of manufacturing routes for chiral active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Facilitates the production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Enables the synthesis of high-value chiral flavors, fragrances, and electronic chemicals.

Basic Information

Product Name	(R)-(+)-2,2'-Bis[Di(3,5-Di-T-Butylphenyl)Phosphino]-6,6'-Dimethoxy-1,1'-Biphenyl, Min. 97%
CAS No.	192138-05-9
Molecular Formula	C72H96O2P2
Molecular Weight	1055.48 g/mol
Synonyms	(R)-(+)-DTBM-SEGPHOS; (R)-DTBM-SEGPHOS; (R)-5,5'-Bis[di(3,5-di-tert-butyl-4-methoxyphenyl)phosphino]-4,4'-bi-1,3-benzodioxole; (R)-2,2'-Bis[di(3,5-di-tert-butylphenyl)phosphino]-6,6'-dimethoxy-1,1'-biphenyl; (R)-DTBM-SEGPHOS Ligand; SEGPHOS Derivative; Chiral Bisphosphine Ligand
EINECS	Contact for details

Quality Control

Our (R)-(+)-DTBM-SEGPHOS is manufactured under strict quality systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analysis including HPLC assay, chiral purity determination, and residual solvent analysis to meet the specifications required for sensitive catalytic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Due to its properties of being easily oxidized (store under inert atmosphere) and hygroscopic (moisture-sensitive), it is recommended to store the product under an inert gas (argon or nitrogen) in a cool, dry place. For long-term storage, keep at 2-8°C. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	Min. 97.0%
Chiral Purity (HPLC)	Min. 99.0% ee
Loss on Drying	Max. 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.