Description

Boc-(2Rs,3S)-Ahpa is a protected amino acid derivative, specifically a stereochemically defined building block used in advanced organic synthesis. This compound is critical for the development of peptide-based pharmaceuticals and bioactive molecules, where precise stereochemistry is essential for biological activity. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, process development, and the synthesis of complex peptidomimetics.

Application

• Peptide Synthesis: A key chiral intermediate in solid-phase and solution-phase peptide synthesis for introducing the Ahpa (2-amino-3-hydroxy-4-phenylbutanoic acid) moiety.
• Protease Inhibitor Development: Crucial building block for constructing inhibitors targeting aspartyl proteases like renin, HIV-1 protease, and plasmepsins.
• Pharmaceutical Intermediates: Serves as a high-value intermediate in the synthesis of active pharmaceutical ingredients (APIs) for cardiovascular and antiviral therapies.
• Chemical Biology Research: Used in the design and synthesis of molecular probes to study enzyme mechanisms and protein-protein interactions.
• Process Chemistry & Scale-up: Employed in the development of scalable synthetic routes for GMP production of peptide-derived drugs.

Basic Information

Product Name	Boc-(2Rs,3S)-Ahpa
CAS No.	191849-93-1
Molecular Formula	C16H23NO5
Molecular Weight	309.36 g/mol
Synonyms	(2R,3S)-3-Amino-2-hydroxy-4-phenylbutanoic acid N-tert-butyloxycarbonyl derivative; Boc-Ahpa-OH; tert-Butyl ((2R,3S)-3-amino-2-hydroxy-4-phenyl-1-oxobutan-1-yl)carbamate; (2R,3S)-2-Hydroxy-3-[(tert-butoxycarbonyl)amino]-4-phenylbutanoic acid; N-Boc-(2R,3S)-Ahpa; (2R,3S)-Ahpa(Boc)-OH; Boc-(2R,3S)-AHPBA
EINECS	Contact for details

Quality Control

Our Boc-(2Rs,3S)-Ahpa is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for stereochemical purity and identity confirmation by NMR and mass spectrometry. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP requirements for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. For long-term storage, consider storage under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% de (diastereomeric excess)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.