Description

(R)-Cth-Jafaphos is a chiral phosphine ligand of significant interest in asymmetric catalysis. Its value lies in its ability to induce high enantioselectivity in transition metal-catalyzed reactions, which is critical for the efficient synthesis of single-enantiomer compounds. This product is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control.

Application

• As a chiral ligand in asymmetric hydrogenation reactions for pharmaceutical intermediates.
• Catalyst component for enantioselective C-C bond formation, such as cross-coupling and allylic substitution.
• Use in the synthesis of enantiomerically pure agrochemicals and flavors/fragrances.
• Key reagent in academic and industrial research for developing new catalytic methodologies.
• Potential application in the synthesis of chiral materials and ligands for other metal complexes.

Basic Information

Product Name	(R)-Cth-Jafaphos
CAS No.	191803-52-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(R)-Jafaphos; (R)-Cth-Jafaphos Ligand; (R)-2-[(Diphenylphosphino)methyl]-4-(1-methylethyl)-4,5-dihydrooxazole; (R)-4-Isopropyl-2-[(diphenylphosphino)methyl]-4,5-dihydrooxazole; (R)-2-[(Diphenylphosphino)methyl]-4-isopropyl-4,5-dihydrooxazole; (R)-4-Isopropyl-2-(diphenylphosphinomethyl)-2-oxazoline; (R)-JOSIPHOS-type ligand variant
EINECS	Contact for details

Quality Control

Our (R)-Cth-Jafaphos is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is characterized and tested to meet rigorous internal specifications suitable for demanding catalytic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral purity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Due to its sensitivity, the container should be kept sealed to minimize exposure to air and moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.