Description

Boc-(R)-2-(Aminomethyl)-3-Methylbutanoic Acid is a high-purity, non-natural amino acid derivative featuring a tert-butoxycarbonyl (Boc) protecting group on the amine functionality. This compound is a critical chiral building block for the synthesis of complex peptides and peptidomimetics, enabling precise control over molecular structure and stereochemistry. It is primarily utilized by pharmaceutical and biotechnology R&D teams for developing novel therapeutic agents, including protease inhibitors and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for targeted therapies.
• Peptide Synthesis: Serves as a protected amino acid building block in solid-phase and solution-phase peptide synthesis (SPPS).
• Protease Inhibitor Development: Used to construct pharmacophores for inhibitors targeting various proteases (e.g., HIV protease, thrombin).
• Bioconjugation & Labeling: The carboxylic acid group allows for conjugation to other molecules, carriers, or fluorescent labels for biochemical studies.
• Chemical Biology Research: Employed in the design and synthesis of peptide-based probes to study enzyme function and protein-protein interactions.
• Academic & Contract Research: A valuable reagent for universities and CROs engaged in medicinal chemistry and organic synthesis projects.

Basic Information

Product Name	Boc-(R)-2-(Aminomethyl)-3-Methylbutanoic Acid
CAS No.	191664-14-9
Molecular Formula	C11H21NO4
Molecular Weight	231.29 g/mol
Synonyms	(R)-2-((tert-Butoxycarbonyl)aminomethyl)-3-methylbutanoic acid; (R)-2-((Boc-amino)methyl)-3-methylbutyric acid; Boc-D-2-Aminomethyl-3-methylbutyric acid; (R)-N-Boc-2-(aminomethyl)-3-methylbutanoic acid; (2R)-2-({[(tert-butoxy)carbonyl]amino}methyl)-3-methylbutanoic acid; tert-Butyl (R)-(1-carboxy-2-methylpropyl)carbamate; Boc-D-Aib-OH (Aib = 2-(aminomethyl)-3-methylbutanoic acid)
EINECS	Contact for details

Quality Control

Our Boc-(R)-2-(Aminomethyl)-3-Methylbutanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure enantiomeric purity and identity confirmation by spectroscopic methods. We provide comprehensive Certificates of Analysis (COA) detailing purity, assay, and impurity profiles to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.