Description

2-Bromo-4-Cyano-Alpha,Alpha,α-Trifluoroanisole is a high-value, multi-functional aromatic building block characterized by its bromine, cyano, and trifluoromethoxy substituents. This compound matters for its unique reactivity profile, enabling precise molecular construction in advanced synthetic pathways. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly those requiring trifluoromethoxy and halogenated aromatic motifs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the bromine and cyano groups serve as handles for further functionalization.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for electronic chemicals and advanced materials due to its aromatic core and halogen/cyano substituents.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig aminations.
• Nucleophilic Aromatic Substitution: The electron-deficient ring, activated by the cyano and trifluoromethoxy groups, facilitates substitution reactions.
• Fluorine Chemistry Research: A valuable compound for studying the effects of the trifluoromethoxy group on reactivity and physicochemical properties in medicinal chemistry.

Basic Information

Product Name	2-Bromo-4-Cyano-Alpha,Alpha,α-Trifluoroanisole
CAS No.	191602-89-8
Molecular Formula	C9H3BrF3NO
Molecular Weight	278.03 g/mol
Synonyms	2-Bromo-4-cyano-α,α,α-trifluoroanisole; 1-Bromo-2-cyano-5-(trifluoromethoxy)benzene; 2-Bromo-4-cyanotrifluoromethoxybenzene; 2-Bromo-4-cyano-α,α,α-trifluoromethyl phenyl ether; 5-Bromo-2-(trifluoromethoxy)benzonitrile; 2-Bromo-4-cyano-1-(trifluoromethoxy)benzene; Benzene, 1-bromo-2-cyano-5-(trifluoromethoxy)-; 2-Bromo-4-cyano-α,α,α-trifluoromethoxybenzene
EINECS	Contact for details

Quality Control

Our 2-Bromo-4-Cyano-Alpha,Alpha,α-Trifluoroanisole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports compliance with cGMP, ISO, and other relevant regulatory frameworks for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The compound may be light-sensitive and should be handled under an inert atmosphere for prolonged stability. Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (GC)	≥97.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.