Description

1-n-Boc-(2S,4S)-4-Hydroxy-2-(Hydroxymethyl) Pyrrolidine is a high-purity, chiral pyrrolidine derivative that serves as a critical building block in advanced organic synthesis. Its value lies in its dual functionalization with a Boc-protected amine and hydroxyl groups, enabling precise stereochemical control in complex molecule assembly. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for developing active pharmaceutical ingredients (APIs) and novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug molecules, particularly protease inhibitors and other biologically active compounds.
• Peptidomimetics Research: Used in the design and construction of peptidomimetic scaffolds to modulate protein-protein interactions.
• Asymmetric Synthesis: Employed as a versatile chiral auxiliary or starting material in stereoselective catalytic reactions.
• API Development: Integral to the research and process development stages for new Active Pharmaceutical Ingredients (APIs).
• Chemical Biology Probes: Serves as a precursor for labeled compounds and molecular probes used in mechanistic studies.
• Custom Synthesis: A foundational material for contract research and manufacturing organizations (CROs/CMOs) offering bespoke chemical services.

Basic Information

Product Name	1-n-Boc-(2S,4S)-4-Hydroxy-2-(Hydroxymethyl) Pyrrolidine
CAS No.	191280-88-3
Molecular Formula	C11H21NO4
Molecular Weight	231.29 g/mol
Synonyms	(2S,4S)-1-(tert-Butoxycarbonyl)-4-hydroxy-2-(hydroxymethyl)pyrrolidine; (2S,4S)-1-Boc-4-hydroxy-2-(hydroxymethyl)pyrrolidine; (2S,4S)-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-methanol; (2S,4S)-4-Hydroxy-2-(hydroxymethyl)-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester; 1-Boc-(2S,4S)-4-hydroxy-2-(hydroxymethyl)pyrrolidine; (2S,4S)-1-Boc-4-hydroxy-2-pyrrolidinemethanol; (2S,4S)-1-(tert-Butyloxycarbonyl)-4-hydroxy-2-(hydroxymethyl)pyrrolidine
EINECS	Contact for details

Quality Control

Our 1-n-Boc-(2S,4S)-4-Hydroxy-2-(Hydroxymethyl) Pyrrolidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.