Description

R-Sulindac Sulfoxide is a high-purity, stereochemically defined pharmaceutical intermediate and reference standard. This compound is a key chiral metabolite and precursor in the synthesis and analytical profiling of the non-steroidal anti-inflammatory drug (NSAID) Sulindac. It is essential for researchers and manufacturers in the pharmaceutical industry requiring precise enantiomeric control for drug development, metabolic studies, and quality control processes.

Application

• Pharmaceutical Intermediate: Critical chiral building block in the synthesis of the active pharmaceutical ingredient (API) Sulindac.
• Analytical Reference Standard: Used for method development, validation, and quantification in HPLC, LC-MS, and chiral analysis to ensure drug purity and consistency.
• Metabolite Studies: Employed in pharmacokinetic and pharmacodynamic research to study the metabolic pathway and chiral inversion of Sulindac.
• Process Chemistry & R&D: Serves as a starting material or reagent in route scouting and optimization for NSAID manufacturing.
• Quality Control & Assurance: Provides a certified standard for identity and assay testing of bulk drugs and finished dosage forms.
• Regulatory Submissions: Supports drug master files (DMFs) and regulatory dossiers with well-characterized reference substances.

Basic Information

Product Name	R-Sulindac Sulfoxide
CAS No.	190967-68-1
Molecular Formula	C20H17FO3S
Molecular Weight	356.41 g/mol
Synonyms	(R)-Sulindac Sulfoxide; (R)-5-Fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid; (R)-Z-5-Fluoro-2-methyl-1-[[p-(methylsulfinyl)benzylidene]indene-3-acetic acid; (R)-(-)-Sulindac Sulfoxide; R-Sulindac Sulphoxide; (R)-Sulindac S-Oxide; (R)-MK-231
EINECS	Contact for details

Quality Control

Our R-Sulindac Sulfoxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity by HPLC, to ensure it meets stringent specifications for pharmaceutical use. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess. We support compliance with cGMP, ICH Q7, and relevant pharmacopeial guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% (R-isomer)
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.