Description

2,2-Difluoro-Benzo[1,3]Dioxole-5-Boronic Acid is a high-value organoboron building block, specifically a difluorinated benzodioxole boronic acid derivative. Its core value lies in enabling the synthesis of complex molecules through reliable Suzuki-Miyaura cross-coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical and advanced materials sectors who require precise fluorination patterns and heterocyclic scaffolds in their target molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates containing the benzodioxole moiety with fluorine substitution.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the difluorobenzodioxole structure imparts specific biological activity and stability.
• Material Science: Serves as a monomer or building block for creating specialized polymers, liquid crystals, and organic electronic materials requiring fluorinated aromatic units.
• Chemical Research: A versatile reagent in academic and industrial R&D for constructing complex organic frameworks via palladium-catalyzed cross-coupling methodologies.
• Ligand Preparation: Can be utilized to synthesize novel bidentate or polydentate ligands for catalysis and coordination chemistry.

Basic Information

Product Name	2,2-Difluoro-Benzo[1,3]Dioxole-5-Boronic Acid
CAS No.	190903-71-0
Molecular Formula	C7H5BF2O4
Molecular Weight	201.93 g/mol
Synonyms	5-Borono-2,2-difluoro-1,3-benzodioxole; 2,2-Difluoro-1,3-benzodioxole-5-boronic acid; (2,2-Difluorobenzo[d][1,3]dioxol-5-yl)boronic acid; 2,2-Difluorobenzodioxole-5-boronic Acid; 190903-71-0; (2,2-Difluoro-1,3-benzodioxol-5-yl)boronic acid
EINECS	Contact for details

Quality Control

Our 2,2-Difluoro-Benzo[1,3]Dioxole-5-Boronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided and available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥95% (Typical 97-99%)
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.