Description

1-n-Boc-5-Oxo-1,4-Diazepane is a high-purity, protected diazepane derivative, a crucial advanced intermediate in modern organic synthesis. Its value lies in providing a versatile and reactive scaffold for constructing complex nitrogen-containing heterocycles, which are core structures in numerous active pharmaceutical ingredients. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, particularly those focused on developing new therapeutic agents and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel diazepane and piperazine-based drug candidates, including potential central nervous system (CNS) agents and enzyme inhibitors.
• Peptidomimetic Research: Used in the design and synthesis of peptidomimetics, where the diazepane ring can mimic peptide turn structures to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Serves as a precursor in the development of new herbicides, fungicides, and insecticides that utilize nitrogen heterocycles for their biological activity.
• Chemical Biology Probes: Employed in the creation of specialized molecular probes and tool compounds for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke intermediates for client projects.
• Academic & Industrial R&D: Fundamental research reagent in universities and corporate R&D labs for methodology development and exploring new chemical space in medicinal chemistry.

Basic Information

Product Name	1-n-Boc-5-Oxo-1,4-Diazepane
CAS No.	190900-21-1
Molecular Formula	C₁₁H₂₀N₂O₃
Molecular Weight	228.29 g/mol
Synonyms	1-[(tert-Butoxy)carbonyl]-5-oxo-1,4-diazepane; tert-Butyl 5-oxo-1,4-diazepane-1-carboxylate; 5-Oxo-1,4-diazepane-1-carboxylic acid tert-butyl ester; 1-Boc-5-oxo-1,4-diazepane; 1,4-Diazepan-5-one, 1-[(1,1-dimethylethoxy)carbonyl]-; Boc-5-oxo-diazepane; 1-N-Boc-5-oxo-1,4-diazepane
EINECS	Contact for details

Quality Control

Our 1-n-Boc-5-Oxo-1,4-Diazepane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. We employ advanced analytical techniques, including HPLC, GC, NMR, and mass spectrometry, for comprehensive identity confirmation and impurity profiling. A detailed Certificate of Analysis (COA) is provided with each batch, documenting purity, assay, and critical physical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 102.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.