Description

(4S,4'S)- 2,2'-(1-Ethylpropylidene)Bis[4,5-Dihydro-4-Phenyl-Oxazole is a high-purity chiral bis(oxazoline) ligand, a critical component in asymmetric synthesis. Its value lies in enabling highly enantioselective transformations, which are essential for producing single-isomer active pharmaceutical ingredients (APIs) and fine chemicals. This product is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for developing and scaling up catalytic processes.

Application

• Asymmetric Catalysis: As a chiral ligand for transition metals (e.g., Cu, Zn, Mg) in enantioselective cyclopropanation, Diels-Alder, and aldol reactions.
• Pharmaceutical Intermediates: Synthesis of chiral building blocks for novel drug candidates and active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical Manufacturing: Key reagent in the production of specialty flavors, fragrances, and advanced materials.
• Academic & Industrial R&D: A versatile tool for methodological development in organic and organometallic chemistry.
• Process Chemistry: Optimization and scale-up of catalytic cycles for cost-effective manufacturing of chiral molecules.

Basic Information

Product Name	(4S,4'S)- 2,2'-(1-Ethylpropylidene)Bis[4,5-Dihydro-4-Phenyl-Oxazole
CAS No.	190791-28-7
Molecular Formula	C24H26N2O2
Molecular Weight	374.48 g/mol
Synonyms	(4S,4'S)-2,2'-(1-Ethylpropylidene)bis(4,5-dihydro-4-phenyloxazole); (S,S)-tert-Butylbis(oxazoline) (common name for related structure); (S,S)-Ph-Box; Chiral BOX Ligand; (4S,4'S)-2,2'-(Pentan-3-ylidene)bis(4,5-dihydro-4-phenyloxazole); (S,S)-2,2'-(1-Ethylpropylidene)bis(4-phenyl-4,5-dihydrooxazole); Ligand for Asymmetric Synthesis; EINECS Contact for details

Quality Control

Our (4S,4'S)- 2,2'-(1-Ethylpropylidene)Bis[4,5-Dihydro-4-Phenyl-Oxazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure high enantiomeric excess (ee) and chemical purity suitable for sensitive catalytic applications. Certificates of Analysis (COA) with full chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.