Description

n-Desmethyl Topotecan is a key pharmaceutical intermediate and metabolite of the topoisomerase I inhibitor, Topotecan. This compound is of critical importance for research and development in oncology, particularly in pharmacokinetic studies and the synthesis of novel anticancer agents. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on cancer therapeutics. Ensuring a reliable supply of high-purity n-Desmethyl Topotecan is essential for advancing drug metabolism and pharmacodynamics (DMPK) studies.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of Topotecan and its related analogs.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical methods for quantifying Topotecan and its metabolites in biological matrices.
• Drug Metabolism & Pharmacokinetics (DMPK) Studies: Essential for investigating the metabolic pathways, clearance, and exposure of Topotecan in preclinical and clinical research.
• Impurity Profiling: Serves as a known impurity or degradation product reference for quality control and regulatory filing of Topotecan Active Pharmaceutical Ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new camptothecin-derived anticancer agents.
• In-vitro Biological Assays: Employed in enzymatic and cellular assays to study topoisomerase I inhibition and mechanism of action.

Basic Information

Product Name	n-Desmethyl Topotecan
CAS No.	190710-79-3
Molecular Formula	C₂₂H₂₃N₃O₅
Molecular Weight	409.44 g/mol
Synonyms	10-Hydroxy-9-[(dimethylamino)methyl]-(S)-camptothecin; (S)-10-Hydroxy-9-((dimethylamino)methyl)-20-oxo-1H,5H,15H,17H-oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dicarboxylic acid methyl ester; 9-Desmethyl Topotecan; Topotecan Impurity F; Topotecan Metabolite; SKF 104864-A
EINECS	Contact for details

Quality Control

Our n-Desmethyl Topotecan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your regulatory and R&D needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.