Description

Ritonavir o-β-D-Glucuronide is a crucial metabolite reference standard of the antiretroviral drug Ritonavir. This compound is essential for pharmaceutical research and development, particularly in the study of drug metabolism and pharmacokinetics (DMPK). It is primarily used by analytical laboratories and pharmaceutical companies engaged in bioanalytical method development, metabolite identification, and regulatory compliance testing for antiviral therapies.

Application

• Metabolite Reference Standard: Serves as a certified standard for the quantitative and qualitative analysis of Ritonavir metabolites in biological matrices.
• Drug Metabolism & Pharmacokinetics (DMPK) Studies: Critical for understanding the metabolic pathway, clearance, and bioavailability of Ritonavir in preclinical and clinical research.
• Bioanalytical Method Development & Validation: Used to develop and validate sensitive LC-MS/MS or HPLC methods for therapeutic drug monitoring and pharmacokinetic profiling.
• Regulatory Submissions: Provides essential data for Investigational New Drug (IND) and New Drug Application (NDA) filings to health authorities like the FDA and EMA.
• Impurity Profiling: Aids in the identification and characterization of glucuronidated impurities or degradation products in drug substance and product stability studies.
• In-vitro Metabolism Studies: Utilized in assays with liver microsomes or hepatocytes to investigate phase II conjugation reactions.

Basic Information

Product Name	Ritonavir o-β-D-Glucuronide
CAS No.	190649-36-6
Molecular Formula	C40H53N7O14S
Molecular Weight	887.96 g/mol
Synonyms	Ritonavir Glucuronide; Ritonavir O-Glucuronide; RTV-G; Ritonavir β-D-Glucuronide; N-{2-Hydroxy-1(S)-[[(2-isopropyl-4-thiazolyl)methyl]sulfonyl]amino]-3(S)-phenylpropyl}decahydro-2(S)-isoquinolinecarboxamide O-β-D-Glucopyranosiduronic Acid; L-735,524 Glucuronide; Norvir Glucuronide
EINECS	Contact for details

Quality Control

Our Ritonavir o-β-D-Glucuronide is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for research and analytical applications. Each batch is characterized and tested using advanced analytical techniques, including HPLC and LC-MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profile is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.