Description

2-Pyrrolidinecarboxamide,n-2-Propynyl-,(S)-(9Ci) is a chiral, propargylated pyrrolidine derivative, a high-value building block in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of pharmaceuticals and bioactive molecules, particularly those targeting the central nervous system. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for creating novel therapeutic agents and conducting asymmetric synthesis.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of new drug candidates, particularly in neurology and psychiatry.
• Asymmetric Synthesis: Used as a building block or ligand precursor in catalytic asymmetric reactions to create enantiomerically pure compounds.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and library synthesis for lead optimization.
• Agrochemical Development: Serves as an intermediate in the synthesis of novel, biologically active crop protection agents.
• Bioconjugation & Probe Synthesis: The propargyl group enables click chemistry (e.g., CuAAC) for labeling, bioconjugation, or creating chemical probes.
• Academic & Institutional Research: Utilized in universities and research institutes for methodological development in organic and medicinal chemistry.

Basic Information

Product Name	2-Pyrrolidinecarboxamide,n-2-Propynyl-,(S)-(9Ci)
CAS No.	190392-27-9
Molecular Formula	C8H12N2O
Molecular Weight	152.19 g/mol
Synonyms	(S)-N-(Prop-2-yn-1-yl)pyrrolidine-2-carboxamide; (S)-1-(Prop-2-ynyl)-2-pyrrolidinecarboxamide; (S)-N-Propargyl-prolinamide; (2S)-N-(Prop-2-yn-1-yl)pyrrolidine-2-carboxamide; (S)-N-(2-Propynyl)-2-pyrrolidinecarboxamide; Prolinamide, N-2-propynyl-, (S)-; (S)-N-Propargyl-2-pyrrolidinecarboxamide; L-Proline, N-(2-propynyl)amide
EINECS	Contact for details

Quality Control

Our 2-Pyrrolidinecarboxamide,n-2-Propynyl-,(S)-(9Ci) is produced under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as chiral purity, chemical assay, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting our customers' regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.