Description

n-Boc-D-Valine N'-Methoxy-N'-Methylamide is a protected amino acid derivative widely utilized as a crucial chiral building block in advanced organic synthesis. This compound matters for its role in facilitating the controlled construction of complex peptide and peptidomimetic structures, enabling research and development in targeted therapeutic areas. It is primarily needed by pharmaceutical R&D teams, process chemists, and fine chemical manufacturers engaged in the synthesis of active pharmaceutical ingredients (APIs), protease inhibitors, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of peptide-based drugs and protease inhibitors.
• Peptidomimetic Research: Used to introduce the D-valine residue with orthogonal protection, essential for creating stable, bioavailable peptide analogs.
• Solid-Phase Peptide Synthesis (SPPS): Serves as a protected amino acid derivative for the controlled elongation of peptide chains in combinatorial chemistry.
• API Development: Employed in process chemistry for constructing complex molecular scaffolds in pre-clinical and clinical candidate molecules.
• Chemical Biology Probes: Utilized in the synthesis of labeled or modified peptides for studying enzyme-substrate interactions and cellular pathways.
• Asymmetric Synthesis: Acts as a source of chiral induction in the preparation of non-proteinogenic amino acids and other fine chemicals.

Basic Information

Product Name	n-Boc-D-Valine N'-Methoxy-N'-Methylamide
CAS No.	190260-92-5
Molecular Formula	C13H26N2O4
Molecular Weight	274.36 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-D-valine N'-methoxy-N'-methylamide; Boc-D-Val-NH-OMe; Boc-D-Valine methoxy methyl amide; tert-Butyl ((R)-1-((methoxy(methyl)amino)-3-methyl-1-oxobutan-2-yl)carbamate; D-Valine, N-[(1,1-dimethylethoxy)carbonyl]-, N-methoxy-N-methylamide; Boc-D-Val-OMe, N-Me; (2R)-2-[[(tert-Butoxy)carbonyl]amino]-3-methyl-N-methoxy-N-methylbutanamide
EINECS	Contact for details

Quality Control

Our n-Boc-D-Valine N'-Methoxy-N'-Methylamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.