Description

Tris(3,5-Di-tert-Butylphenyl)Phosphine is a sterically hindered tertiary phosphine ligand, prized for its exceptional stability and electron-donating properties. This compound is a critical catalyst component in cross-coupling reactions, enabling the efficient synthesis of complex organic molecules. It is essential for R&D and production in the pharmaceutical, agrochemical, and advanced materials sectors where robust and selective catalytic processes are required.

Application

• Homogeneous Catalysis: A key ligand in palladium-catalyzed cross-coupling reactions such as Suzuki-Miyaura, Heck, and Buchwald-Hartwig aminations.
• Pharmaceutical Intermediates: Facilitates the synthesis of complex, high-value drug candidates and active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides requiring selective bond formation.
• Polymer & Material Science: Employed in the catalytic synthesis of specialty polymers and organic electronic materials.
• Fine Chemical Manufacturing: Enables precise and efficient synthesis routes for specialty and performance chemicals.
• Academic & Industrial R&D: A valuable tool for developing new catalytic methodologies and exploring novel chemical transformations.

Basic Information

Product Name	Tris(3,5-Di-tert-Butylphenyl)Phosphine
CAS No.	189756-42-1
Molecular Formula	C42H63P
Molecular Weight	622.92 g/mol
Synonyms	Tris(3,5-di-tert-butylphenyl)phosphine; Tris(3,5-bis(1,1-dimethylethyl)phenyl)phosphine; 3,5-Di-tert-butylphenylphosphine; Tris(3,5-di-tert-butylphenyl)phosphane; Ligand SPhos (Note: SPhos is a closely related but distinct ligand); Tri(3,5-di-tert-butylphenyl)phosphine; Phosphorous tris(3,5-di-tert-butylphenyl) ester
EINECS	Contact for details

Quality Control

Our Tris(3,5-Di-tert-Butylphenyl)Phosphine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, critical for catalytic performance. Each lot is analyzed using advanced techniques including HPLC, NMR, and elemental analysis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at room temperature (15-25°C) under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	245 - 250 °C
Heavy Metals	< 20 ppm
Residue on Ignition	< 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.