Description

4-Chloro-3-Methoxybenzonitrile is a versatile aromatic nitrile building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both chloro and methoxy substituents, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the benzonitrile core provides essential bioactivity.
• Liquid Crystal & OLED Materials: Serves as a precursor for synthesizing specialized aromatic compounds used in electronic display technologies and organic light-emitting diodes.
• Polymer & Resin Modifiers: Employed to introduce specific functional groups into polymer chains, enhancing material properties like thermal stability or chemical resistance.
• Dyestuff & Pigment Intermediate: Acts as a starting material for manufacturing complex dyes and high-performance pigments.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions (e.g., Suzuki, Sonogashira) due to the reactive chloro group, enabling rapid diversification in medicinal chemistry.
• Chemical Research & Development: A valuable reagent for exploring new synthetic methodologies and creating compound libraries for high-throughput screening.

Basic Information

Product Name	4-Chloro-3-Methoxybenzonitrile
CAS No.	189628-40-8
Molecular Formula	C8H6ClNO
Molecular Weight	167.59 g/mol
Synonyms	4-Chloro-3-methoxybenzonitrile; 3-Methoxy-4-chlorobenzonitrile; 4-Chloro-m-anisonitrile; 4-Chloro-3-methoxy-phenyl cyanide; 2-Chloro-5-cyanomethoxybenzene; 4-Chloro-3-methoxybenzenecarbonitrile; 4-Chloro-3-methoxybenzene-1-carbonitrile; Benzonitrile, 4-chloro-3-methoxy-
EINECS	Contact for details

Quality Control

Our 4-Chloro-3-Methoxybenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee it meets your specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.