Description

7 β - Amino - 3 - [4 - Pyridyl - 2 - Thiazole Sulfur Radical ] - 3 - Cephem - 4 - Carboxylic Acid CAS NO 189345-52-6 is a key advanced pharmaceutical intermediate belonging to the cephalosporin class of β-lactam antibiotics. This compound is critical for the synthesis of next-generation antibiotics, offering a sophisticated chemical scaffold for developing potent antimicrobial agents. It is primarily utilized by pharmaceutical R&D departments, fine chemical manufacturers, and contract research organizations (CROs) focused on novel anti-infective drug development.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a crucial building block in the multi-step synthesis of novel cephalosporin antibiotics.
• Pharmaceutical Research & Development: Used as a reference standard and a starting material in medicinal chemistry programs targeting bacterial infections.
• Structure-Activity Relationship (SAR) Studies: The unique 4-pyridyl-2-thiazole moiety allows for exploration of new antibacterial spectra and potency.
• Fine Chemical Manufacturing: Employed in the production of high-value, specialized intermediates for the pharmaceutical supply chain.
• Antibiotic Resistance Research: Investigated for developing new compounds to combat multidrug-resistant bacterial strains.

Basic Information

Product Name	7 β - Amino - 3 - [4 - Pyridyl - 2 - Thiazole Sulfur Radical ] - 3 - Cephem - 4 - Carboxylic Acid
CAS No.	189345-52-6
Molecular Formula	C15H12N4O3S2
Molecular Weight	360.41 g/mol
Synonyms	7β-Amino-3-[(4-pyridyl-2-thiazolyl)thio]-3-cephem-4-carboxylic Acid; 7β-Amino-3-(4-pyridin-2-yl-1,3-thiazol-2-ylsulfanyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid; (6R,7R)-7-Amino-3-[(4-pyridin-2-yl-1,3-thiazol-2-yl)sulfanyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid; Cephalosporin Derivative 189345-52-6; 7-ACA Pyridylthiazole Derivative; 7β-Amino-3-(4-pyridyl-2-thiazolylthio)-3-cephem-4-carboxylic Acid
EINECS	Contact for details

Quality Control

Our 7 β - Amino - 3 - [4 - Pyridyl - 2 - Thiazole Sulfur Radical ] - 3 - Cephem - 4 - Carboxylic Acid is manufactured under strict quality systems suitable for pharmaceutical intermediate applications. We provide comprehensive analytical data to support your regulatory filings. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every batch, ensuring traceability and compliance with cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider desiccants or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.