Description

Tissue Plasminogen Activator, Human is a serine protease enzyme that plays a critical role in the fibrinolytic system, catalyzing the conversion of plasminogen to plasmin to break down blood clots. This recombinant protein is essential for therapeutic and research applications where precise thrombolytic activity is required. It is a vital reagent for pharmaceutical manufacturers, clinical research organizations, and diagnostic developers focused on cardiovascular disease, stroke treatment, and hemostasis studies.

Application

• Thrombolytic Drug Formulation: Active pharmaceutical ingredient (API) in the production of medications for acute ischemic stroke, myocardial infarction, and pulmonary embolism.
• Biomedical Research: Used as a standard or reagent in in vitro and in vivo studies of fibrinolysis, thrombosis models, and vascular biology.
• Diagnostic Kit Production: A key component in the calibration and development of clinical diagnostic assays for fibrinolytic activity and coagulation disorders.
• Cell Culture & Tissue Engineering: Employed in research applications to study cell migration, angiogenesis, and extracellular matrix remodeling.
• Reference Standard: Serves as a high-purity standard for quality control and potency assays in pharmaceutical manufacturing and regulatory submissions.

Basic Information

Product Name	Tissue Plasminogen Activator, Human
CAS No.	189263-81-8
Molecular Formula	C2560H3924N746O781S44
Molecular Weight	~59 kDa (Glycosylated form)
Synonyms	Alteplase; t-PA; rt-PA; Recombinant Tissue Plasminogen Activator; Activase®; Actilyse®; Plasminogen Activator, Tissue-Type; TPA Human; Fibrinolysin Activator; EC 3.4.21.68
EINECS	Contact for details

Quality Control

Our Tissue Plasminogen Activator, Human is manufactured under strict quality systems. Each batch is tested to ensure high purity, biological activity, and consistency, meeting standards suitable for research and pharmaceutical development. A comprehensive Certificate of Analysis (COA) is provided, detailing specifications for identity, purity, potency, and impurities. We support compliance with relevant pharmacopeial guidelines (e.g., USP, EP) and cGMP principles where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store frozen at -20°C or below. For long-term storage, maintain at -70°C. The product is hygroscopic (moisture-sensitive). Avoid repeated freeze-thaw cycles. Aliquot upon receipt to preserve stability.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear solution
Identification (HPLC/MS)	Conforms to reference standard
Purity (SDS-PAGE & HPLC)	≥ 95%
Biological Activity (Clot Lysis)	≥ 500,000 IU/mg
Endotoxin	< 1.0 EU/mg
Protein Content	Determined by UV absorbance
Residual Host Cell DNA	< 10 pg/mg
Residual Host Cell Protein	< 50 ppm
Sterility (where applicable)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.