Description

(Cyclo (Glu22-Lys26),Leu27)-Pth (1-31) Amide (Human) CAS NO 188899-65-2 is a synthetic, cyclic peptide fragment derived from human parathyroid hormone (PTH). This compound is of significant interest in biochemical and pharmaceutical research due to its role in studying calcium metabolism and bone physiology. It serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate for researchers and developers in the fields of endocrinology and metabolic bone disease therapeutics.

Application

• Pharmaceutical Research & Development: As a key intermediate or reference standard in the development of novel PTH-related therapies for osteoporosis and hypoparathyroidism.
• Biochemical Assay Development: For use in receptor binding studies, activity assays, and the calibration of analytical methods to study PTH pathway interactions.
• Academic & Clinical Research: Investigating the structure-activity relationships (SAR) of PTH analogs and their effects on calcium and phosphate homeostasis.
• Peptide Chemistry Studies: Serving as a model compound for studying the synthesis, stability, and formulation of complex cyclic peptides.
• Quality Control Reference: Used as a certified reference material (CRM) to ensure the identity, purity, and potency of PTH-based pharmaceutical products during manufacturing QC.

Basic Information

Item	Details
Product Name	(Cyclo (Glu22-Lys26),Leu27)-Pth (1-31) Amide (Human)
CAS No.	188899-65-2
Molecular Formula	C152H246N44O45
Molecular Weight	~3480.9 g/mol
Synonyms	Cyclo(22-26)[Glu22,Lys26]hPTH(1-31)NH2; [Cyclo(Glu22-Lys26),Leu27]hPTH(1-31) amide; Human Parathyroid Hormone (1-31) cyclic analog; PTH (1-31) cyclic lactam analog; hPTH(1-31) amide, cyclic(Glu22-Lys26),Leu27-; Cyclic PTH fragment 1-31; PTH analog; CAS 188899-65-2
EINECS	Contact for details

Quality Control

Our (Cyclo (Glu22-Lys26),Leu27)-Pth (1-31) Amide (Human) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis, to ensure it meets the stringent requirements for research and development use. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.