Description

Boc-3-Chloro-Dl-Phenylalanine is a protected amino acid derivative of significant importance in synthetic organic and medicinal chemistry. This compound serves as a crucial chiral building block for the construction of complex peptides and peptidomimetics, enabling the introduction of a chlorinated phenylalanine moiety under controlled conditions. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, process development, and the synthesis of bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs) and therapeutic peptides.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate a modified phenylalanine residue into peptide chains.
• Chemical Biology Research: Employed in the study of protein-protein interactions and the development of enzyme inhibitors or receptor modulators.
• Process Chemistry: Serves as a starting material or intermediate in the scalable synthesis of more complex, target-oriented molecules.
• Protecting Group Strategy: The tert-butoxycarbonyl (Boc) group allows for orthogonal deprotection strategies in multi-step synthetic sequences.

Basic Information

Product Name	Boc-3-Chloro-Dl-Phenylalanine
CAS No.	188814-25-7
Molecular Formula	C₁₄H₁₈ClNO₄
Molecular Weight	299.75 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-3-chloro-DL-phenylalanine; (RS)-2-[(tert-Butoxycarbonyl)amino]-3-(3-chlorophenyl)propanoic acid; Boc-3-Cl-DL-Phe-OH; 3-Chloro-DL-phenylalanine, N-Boc-; N-Boc-3-chloro-DL-phenylalanine; DL-3-Chlorophenylalanine N-t-Boc derivative; tert-Butyl (3-chloro-DL-phenylalanyl)carbamate
EINECS	Contact for details

Quality Control

Our Boc-3-Chloro-Dl-Phenylalanine is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles as determined by advanced analytical techniques. Our quality commitment aligns with the standards expected in fine chemical and pharmaceutical intermediate supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Purity (Chiral HPLC)	DL-mixture (Racemic)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.