Description

Ziprasidone Sulfoxide is a key pharmaceutical intermediate and metabolite of the antipsychotic drug ziprasidone. Its precise synthesis and high purity are critical for research into drug metabolism, pharmacokinetics, and the development of analytical reference standards. This compound is essential for pharmaceutical R&D laboratories, analytical testing facilities, and manufacturers engaged in the production or quality control of ziprasidone-based medications.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the identification and quantification of ziprasidone and its metabolites in analytical methods.
• Metabolite Research: Used in preclinical and clinical studies to investigate the metabolic pathways, bioavailability, and excretion profiles of ziprasidone.
• Analytical Method Development: Critical for developing and validating high-performance liquid chromatography (HPLC), LC-MS/MS, and other chromatographic assays in bioanalysis.
• Impurity Profiling: Employed as a known impurity standard to monitor and control the quality of ziprasidone active pharmaceutical ingredient (API) during manufacturing.
• Pharmacokinetic Studies: Utilized in studies to understand the absorption, distribution, metabolism, and excretion (ADME) of the parent drug.
• Regulatory Submissions: Provides necessary data and standards for regulatory filings with agencies like the FDA and EMA.

Basic Information

Product Name	Ziprasidone Sulfoxide
CAS No.	188797-80-0
Molecular Formula	C21H21ClN4O2S
Molecular Weight	428.94 g/mol
Synonyms	5-[2-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one S-Oxide; Ziprasidone S-Oxide; Ziprasidone Sulfone (common misnomer); CP-88,059-1; Geodon Sulfoxide; Zeldox Sulfoxide
EINECS	Contact for details

Quality Control

Our Ziprasidone Sulfoxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee traceability and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C (59-77°F), in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C to maximize stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.