Description

Fmoc-1-Amino-1-Cycloheptanecarboxylic Acid CAS NO 188751-56-6 is a specialized, non-proteinogenic amino acid derivative featuring a seven-membered cycloheptane ring, protected by a base-labile 9-fluorenylmethoxycarbonyl (Fmoc) group. This compound is critically important for introducing conformational constraints and unique steric properties into synthetic peptide chains, enabling the development of novel bioactive molecules. It is primarily utilized by research scientists and process chemists in pharmaceutical R&D and biotechnology for advanced peptide synthesis, particularly in the development of peptide-based therapeutics and diagnostic tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the Fmoc-strategy synthesis of peptides containing constrained, non-natural amino acids to modulate biological activity and stability.
• Peptidomimetic Drug Discovery: Used to create peptide analogs and mimetics with enhanced metabolic stability, receptor selectivity, and oral bioavailability for therapeutic applications.
• Combinatorial Chemistry Libraries: Serves as a valuable scaffold in generating diverse chemical libraries for high-throughput screening against biological targets.
• Structure-Activity Relationship (SAR) Studies: Employed to investigate the impact of ring size and conformational restriction on the potency and function of peptide leads.
• Bioconjugation and Probe Development: Can be incorporated into peptides designed for labeling, imaging, or targeted delivery applications.
• Academic and Industrial Research: A fundamental reagent for synthetic organic chemistry and medicinal chemistry research exploring novel amino acid architectures.

Basic Information

Product Name	Fmoc-1-Amino-1-Cycloheptanecarboxylic Acid
CAS No.	188751-56-6
Molecular Formula	C23H25NO4
Molecular Weight	379.45 g/mol
Synonyms	Fmoc-Achp-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-amino-1-cycloheptanecarboxylic acid; 1-[(9-Fluorenylmethoxycarbonyl)amino]cycloheptane-1-carboxylic acid; Fmoc-1-amino-cycloheptane-1-carboxylic acid; Fmoc-Amino-cycloheptanecarboxylic Acid; N-Fmoc-1-amino-1-cycloheptanecarboxylic acid; 1-Amino-1-cycloheptanecarboxylic acid Fmoc derivative
EINECS	Contact for details

Quality Control

Our Fmoc-1-Amino-1-Cycloheptanecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for advanced peptide synthesis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.