Description

Montelukast Acyl-B-D-Glucuronide is a key metabolite of the leukotriene receptor antagonist Montelukast, formed via glucuronidation. This compound is of critical importance for pharmaceutical research and development, particularly in the areas of drug metabolism and pharmacokinetic (DMPK) studies. It is primarily needed by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in bioanalytical method development, metabolite identification, and regulatory safety testing.

Application

• Reference Standard for Bioanalysis: Serves as a certified reference material (CRM) for the quantification of Montelukast metabolites in biological matrices (e.g., plasma, urine) using LC-MS/MS or HPLC.
• Metabolite Profiling & Identification (Met ID): Essential for characterizing the metabolic pathways of Montelukast and confirming the structure of its acyl glucuronide metabolite.
• Pharmacokinetic (PK) and Toxicokinetic (TK) Studies: Used to understand the absorption, distribution, metabolism, and excretion (ADME) profile of Montelukast and assess exposure to its metabolites.
• Drug-Drug Interaction (DDI) Studies: Employed in studies investigating the potential for metabolic interactions involving UGT enzymes.
• Impurity Standard: Can be used as a specified impurity reference standard for the quality control of Montelukast active pharmaceutical ingredient (API) and finished drug products.
• Stability Indicating Method Development: Aids in developing and validating analytical methods to monitor the stability of Montelukast and the formation of its metabolites.

Basic Information

Product Name	Montelukast Acyl-B-D-Glucuronide
CAS No.	188717-17-1
Molecular Formula	C35H37ClNO7S
Molecular Weight	651.19 g/mol
Synonyms	Montelukast Acyl Glucuronide; Montelukast 1-O-β-Acyl Glucuronide; [R-(E)]-1-[[[1-[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid β-D-Glucopyranosiduronic acid; (1S,2R)-3-(((1-(3-((E)-2-(7-Chloroquinolin-2-yl)vinyl)phenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)propyl)thio)methyl)cyclobutane-1-carboxylic acid β-D-Glucuronide; Montelukast Glucuronide Metabolite; SQ 31,773 Glucuronide
EINECS	Contact for details

Quality Control

Our Montelukast Acyl-B-D-Glucuronide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, LC-MS for identity confirmation, and residual solvent analysis. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided to ensure traceability and compliance with research and regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.