Description

4-Ethynyl-L-Phenylalanine Hydrochloride is a non-natural, chiral amino acid derivative featuring a reactive ethynyl group. This compound is a critical building block in chemical biology and pharmaceutical research, enabling advanced applications through click chemistry and bioconjugation. It is primarily utilized by research institutions and pharmaceutical companies for the development of novel therapeutics, diagnostic agents, and biochemical probes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted drug conjugates, including Antibody-Drug Conjugates (ADCs) and small molecule inhibitors.
• Chemical Biology Research: Used for site-specific protein and peptide labeling via copper-catalyzed azide-alkyne cycloaddition (CuAAC) and other bioorthogonal reactions.
• Proteomics & Biomarker Discovery: Enables the tagging and enrichment of biomolecules for mass spectrometry analysis and activity-based protein profiling (ABPP).
• PET Tracer Development: Serves as a building block for radiolabeled compounds used in Positron Emission Tomography (PET) imaging.
• Material Science: Incorporation into polymers and surfaces to create functionalized materials with specific biological activity.
• Academic & Industrial R&D: Fundamental research tool for studying enzyme mechanisms, metabolic pathways, and protein-protein interactions.

Basic Information

Product Name	4-Ethynyl-L-Phenylalanine Hydrochloride
CAS No.	188640-63-3
Molecular Formula	C11H12ClNO2
Molecular Weight	225.67 g/mol
Synonyms	(S)-2-Amino-3-(4-ethynylphenyl)propanoic acid hydrochloride; L-4-Ethynylphenylalanine HCl; 4-Ethynyl-L-Phe-OH·HCl; 4-Ethynylphenylalanine hydrochloride; p-Ethynyl-L-phenylalanine hydrochloride; Fmoc-4-ethynyl-L-phenylalanine (precursor); 188640-63-3; Click chemistry amino acid
EINECS	Contact for details

Quality Control

Our 4-Ethynyl-L-Phenylalanine Hydrochloride is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.