Description

n-Boc-α-Methyl-D-Serine Methyl Ester is a high-purity, non-natural amino acid derivative featuring a tert-butoxycarbonyl (Boc) protecting group and a methyl ester. This compound is a critical chiral building block for the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, particularly for developing protease inhibitors, bioactive peptides, and other therapeutic agents. Its protected functional groups make it an essential intermediate for solid-phase peptide synthesis (SPPS) and medicinal chemistry applications.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), especially protease inhibitors and hormone analogs.
• Peptide Synthesis: Serves as a protected D-serine derivative for use in Solid-Phase Peptide Synthesis (SPPS) and solution-phase peptide chemistry to introduce modified serine residues.
• Medicinal Chemistry & Drug Discovery: Used in structure-activity relationship (SAR) studies and the construction of peptidomimetic libraries to explore new therapeutic candidates.
• Bioconjugation & Probe Development: Acts as a precursor for synthesizing labeled peptides or affinity probes used in biochemical and diagnostic research.
• Academic & Industrial Research: Employed in organic synthesis laboratories for methodological development and the study of asymmetric synthesis.

Basic Information

Product Name	n-Boc-α-Methyl-D-Serine Methyl Ester
CAS No.	188476-33-7
Molecular Formula	C10H19NO5
Molecular Weight	233.26 g/mol
Synonyms	(R)-2-((tert-Butoxycarbonyl)amino)-2-methyl-3-hydroxypropanoic acid methyl ester; Methyl (R)-2-((tert-butoxycarbonyl)amino)-2-methyl-3-hydroxypropanoate; Boc-D-α-methylserine-OMe; Boc-D-Ser(Me)-OMe; (R)-Methyl 2-((tert-butoxycarbonyl)amino)-2-methyl-3-hydroxypropanoate; D-α-Methylserine, N-Boc, methyl ester; tert-Butyl ((1R)-1-(methoxycarbonyl)-1-methyl-2-hydroxyethyl)carbamate
EINECS	Contact for details

Quality Control

Our n-Boc-α-Methyl-D-Serine Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, identity, and specific impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.