Description

4-Chloro-1-Ethynyl-2-Fluoro-Benzene is a high-purity fluorinated aromatic building block featuring both chloro and ethynyl substituents, making it a versatile intermediate for advanced synthesis. This compound is critical for constructing complex molecular architectures in pharmaceutical and agrochemical research, where precise functional group manipulation is required. It is primarily sought by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and material science industries for applications in cross-coupling reactions and as a precursor to specialized polymers.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a fluorinated aromatic core.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the biological activity imparted by the fluorine atom.
• Material Science Precursor: Acts as a monomer or cross-linking agent in the development of specialty polymers and advanced organic materials.
• Cross-Coupling Reactions: The ethynyl group makes it a valuable substrate for Sonogashira, Glaser, and other metal-catalyzed coupling reactions to create conjugated systems.
• Ligand and Catalyst Development: Utilized in the preparation of sophisticated ligands for catalysis and molecular recognition studies.
• Chemical Research & Development: A versatile reagent for exploring new synthetic methodologies and constructing complex, multi-functional organic molecules.

Basic Information

Product Name	4-Chloro-1-Ethynyl-2-Fluoro-Benzene
CAS No.	188472-71-1
Molecular Formula	C8H4ClF
Molecular Weight	154.57 g/mol
Synonyms	2-Fluoro-4-chloroethynylbenzene; 1-Chloro-4-ethynyl-2-fluorobenzene; 4-Chloro-2-fluoroethynylbenzene; 2-Fluoro-4-chloro-1-ethynylbenzene; 4-Chloro-2-fluorophenylacetylene; (4-Chloro-2-fluorophenyl)ethyne; 1-Ethynyl-4-chloro-2-fluorobenzene; Benzene, 4-chloro-1-ethynyl-2-fluoro-
EINECS	Contact for details

Quality Control

Our 4-Chloro-1-Ethynyl-2-Fluoro-Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flames. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.